Tehran, Iran  ·  +98 21 2610 9506  ·  Knowledge-Based Certified Company
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Knowledge-Based Biotech Company

Pioneering Clinical Biotechnology.

Advancing global health through internationally patented medical devices, novel pharmaceutical formulations, and the world's first in situ tissue-engineered trachea — translating over a decade of focused research into life-saving clinical innovations.

[ HERO — Advanced Tissue Engineering Laboratory at NRITLD / Sterile Environment / 560×420 ]
[ Bio-Artificial Trachea Scaffold Close-Up / 270×180 ]
[ Dr. Ghanavi in Surgical Suite / Masih Daneshvari Hospital / 270×180 ]

12+

Years of R&D

6+

International Patents

1st

Bio-Artificial Trachea Globally

60×

Viral Reduction Factor

7000+

Chemicals Neutralized

About the Founder

A Legacy of Surgical & Scientific Excellence

[ PORTRAIT — Dr. Jalaledin Ghanavi / Professional Medical Headshot / White Coat / 400×530 ]
Head of Tissue
Engineering Dept.

Dr. Jalaledin Ghanavi

General Surgeon · Pulmonologist · Tissue Engineering Scientist

General Surgery Pulmonology Tissue Engineering Regenerative Medicine Nano-Biotechnology

Dr. Jalaledin Ghanavi serves as the Head of the Tissue Engineering Department at the National Research Institute of Tuberculosis and Lung Diseases (NRITLD), affiliated with Shahid Beheshti University of Medical Sciences at Masih Daneshvari Hospital in Tehran, Iran.

With a dual specialization in general surgery and pulmonology, Dr. Ghanavi bridges the gap between clinical practice and translational research — pioneering regenerative approaches to airway reconstruction and developing novel pharmaceutical and biomedical products that have earned international recognition.

Under his leadership, the research team has successfully developed the world's first bio-artificial trachea using in situ tissue engineering methodology, a landmark achievement that eliminates the need for donor organs and immunosuppressive therapy in tracheal reconstruction.

✦ Honors & Distinctions

Tohoku Medical Society AwardTohoku University, Japan — International Research Excellence
Shahid Beheshti University Research AwardOutstanding Contribution to Medical Sciences Research
Editor — Nano-Biotechnology & Tissue Engineering SectionLeading peer-reviewed scientific editorial board
Associate Editor — The International Journal of MycobacteriologyContributing to global infectious disease research discourse
"True innovation in medicine is not measured by complexity, but by the lives it transforms. Our mission is to bring laboratory breakthroughs to the bedside — safely, effectively, and accessibly."
— Dr. Jalaledin Ghanavi, Founder
⬡

Translational Research

Converting scientific discoveries into clinically viable products with rigorous safety validation and regulatory compliance.

◈

Patient-First Innovation

Every device and formulation is designed to minimize invasiveness, reduce side effects, and improve patient quality of life.

⎔

Intellectual Property

A robust portfolio of international patents protecting novel methods that define new standards in biotechnology.

Product Portfolio

Patented Innovations for Global Health

From consumer health devices to clinical-grade pharmaceuticals, every product is rooted in rigorous science, validated through clinical testing, and protected by international patents.

[ PRODUCT — Hookahpo® Filter Device / Attached to Hookah Hose Setup / 420×260 ]
Patented Device

Hookahpo®

The world's first product engineered to remove toxic compounds from hookah smoke. Hookahpo® neutralizes over 7,000 harmful chemicals — including 250 known carcinogens — as well as carbon monoxide, dramatically reducing the health risks associated with waterpipe use through advanced filtration technology.

US Patent No. 9,198,462 Details
[ PRODUCT — Corona Safe Spray / Applied to Surgical Mask Surface / 420×260 ]
Medical Spray

Corona Safe

A surgical and fabric mask protective spray formulated with a natural macrocycle molecule. Corona Safe deactivates the SARS-CoV-2 Spike (S) protein on contact, reducing viral transmission through masks by up to 60 times. Each application provides effective protection for up to 8 hours. Successfully passed all human biocompatibility tests.

US Patent No. 9,198,462 Details
[ PRODUCT — Healina Wound Dressing Spray / Clinical Packaging / 420×260 ]
Medical Device

Healina Wound Dressing Spray

An advanced wound management spray that forms a transparent, breathable protective film over wounds. Healina accelerates the natural healing process while providing a barrier against environmental contaminants and bacterial infection, suitable for surgical wounds and chronic wound care.

Proprietary Formulation Details
[ PRODUCT — Sildipin Pharmaceutical Packaging / Blister + Box / 420×260 ]
Pharmaceutical

Sildipin

A novel pharmaceutical formulation developed for targeted therapeutic applications, combining active pharmaceutical ingredients with an optimized delivery system for enhanced bioavailability and controlled release, designed to improve patient compliance and clinical outcomes.

Rx Pharmaceutical Details
[ PRODUCT — Diclodipin Pharmaceutical Packaging / Clinical Format / 420×260 ]
Pharmaceutical

Diclodipin

A combination pharmaceutical formulation designed for multi-target therapeutic action. Diclodipin represents an innovative approach to polypharmacy reduction by combining complementary active ingredients within a single dosage form, optimizing treatment efficiency.

Rx Pharmaceutical Details
[ PRODUCT — Tracheal Cuff Controller & HHO System / Multi-Device Display / 420×260 ]
Clinical Systems

Tracheal Cuff Controller & HHO System

The Tracheal Cuff Pressure Controlling Device ensures optimal endotracheal tube cuff pressure during mechanical ventilation, preventing tracheal injury. The HHO Gas Generation System represents an innovative approach to clean gas production for clinical and industrial applications.

Tracheal Cuff Controller HHO Gas Generation
Multi-Device Platform Details
Breakthroughs

Landmark Achievements in Regenerative Medicine

Milestone achievements representing world-firsts in clinical biotechnology and public health protection — each validated through rigorous scientific methodology and clinical testing.

[ BREAKTHROUGH — Bio-Artificial Trachea / In Situ Tissue Engineering Process Diagram / 560×280 ]
May 18, 2024

World's First Bio-Artificial Trachea Transplant

After 12 years of continuous research, Dr. Ghanavi and his team successfully transplanted the world's first bio-artificial trachea — achieved without conventional surgery or immunosuppressive drugs.

The breakthrough utilizes a pioneering "in situ tissue engineering" methodology: a biocompatible scaffold is injected at the target site, followed by guided stem cell differentiation into cartilage tissue, and precise placement of epithelial cells to reconstruct a fully functional airway segment within the patient's body.

This represents a paradigm shift in regenerative medicine — eliminating the need for donor organs and the lifelong burden of anti-rejection medication, opening new frontiers for tracheal reconstruction worldwide.

[ EVENT — Corona Safe Unveiling Ceremony / Masih Daneshvari Hospital / Officials Present / 560×280 ]
May 17, 2024

Corona Safe Protective Mask Spray — Commercialized

The Corona Safe protective spray was officially unveiled and commercialized at a ceremony held at Masih Daneshvari Hospital in Tehran. The product successfully passed all required human biocompatibility and safety testing protocols prior to market release.

The natural macrocycle molecule formulation was validated for its ability to deactivate the SARS-CoV-2 Spike protein, offering a practical, accessible layer of protection for healthcare workers and the general public during respiratory disease outbreaks.

Key Supporters: Dr. Alireza Zali & Dr. Peyman Salehi
Credentials

Affiliations & Certifications

[ LOGO — SBMU / 80×80 ]

Shahid Beheshti University

Faculty of Medical Sciences — Research & Clinical Affiliation

[ LOGO — NRITLD / 80×80 ]

NRITLD — Masih Daneshvari

National Research Institute of Tuberculosis & Lung Diseases

[ LOGO — Knowledge-Based Certification / 80×80 ]

Knowledge-Based Company

Certified by Iran's Vice Presidency for Science & Technology

[ SEAL — US Patent Office / 80×80 ]

USPTO Patent Holder

Internationally protected intellectual property portfolio

Research Areas

Core Scientific Domains

Our multidisciplinary research spans from molecular biology to clinical application, driving innovations across six interconnected scientific domains.

01

In Situ Tissue Engineering

Developing scaffold-based regenerative methodologies that enable tissue reconstruction directly within the patient's body, bypassing the need for external bioreactors and complex surgical transplantation.

02

Airway Reconstruction

Pioneering non-surgical tracheal repair using biocompatible scaffolds, directed stem cell differentiation into chondrocytes, and epithelial cell seeding for functional airway regeneration.

03

Antiviral Surface Chemistry

Formulating natural macrocycle molecule-based coatings that deactivate viral surface proteins on contact, creating new defensive layers for personal protective equipment.

04

Smoke Toxicology & Filtration

Researching chemical neutralization of combustion byproducts — targeting carcinogens, heavy metals, and carbon monoxide in waterpipe smoke through novel filtration matrices.

05

Drug Delivery Systems

Designing optimized pharmaceutical formulations with enhanced bioavailability, controlled release profiles, and combination therapies to improve patient compliance and outcomes.

06

Advanced Wound Management

Creating next-generation wound dressing technologies that form protective biofilms, accelerate re-epithelialization, and provide antimicrobial barriers for acute and chronic wound care.

Interested in Partnership or Licensing?

We welcome collaboration with healthcare institutions, pharmaceutical distributors, research organizations, and investors who share our vision for advancing regenerative medicine and patient care.

Contact & Locations

Reach Our Teams

Connect with our research & development headquarters in Tehran or our manufacturing facility in Qazvin for inquiries, partnerships, and procurement.

⬡

R&D Office — Tehran

Address West Unit, 2nd Floor, No. 6, Daneshjoo Blvd., Aqaqia Alley, Velenjak, Tajrish, Shemiranat, District 19, Tehran Province, Iran
Postal 1984833817
Fax +98 21 2610 9505
⚙

Manufacturing Facility — Qazvin

Address Mir-Emad Blvd., Caspian Industrial Town, In front of Shahid Rajaee Power Plant, Tehran–Qazvin Highway, Qazvin Province, Iran
WhatsApp +98 912 349 5671
[ MAP — Tehran R&D Office & Qazvin Manufacturing Facility Locations / Dual Pin Map / 1140×380 ]